Technology aims to improve lung transplant odds

Publié le par brightshine

Even with this high rejection rate, many of the 1,700 U.S. patients who do get lungs suffer a sometimes fatal,There are different configurations of industrial laser marking machine: moving material, hybrid, and flying optics systems. little-understood complication called "primary graft dysfunction." The transplanted lungs just don't work properly, perhaps partly because of the physiological shock of having circulation abruptly restored.

This catastrophe can happen despite a technically flawless surgery. It occurs in about 10 percent of cases at Penn; rates at some centers are two to three times higher.

"This is one of the most painful things for me as a transplant surgeon," Cantu said. "You can do everything absolutely perfectly. You take the patient to the ICU. You talk to the family. Everybody's happy. And 12 hours later, the patient is critically ill."

Cooper was among the first researchers to try to improve out-of-body lung preservation. He developed a cell-free solution that could be pumped through the lung to protect it after removal from the donor.

The XVIVO system being tested at Penn uses a patented solution named for the final developer, Swedish surgeon Stig Steen. Steen Solution helps to cleanse the lung, reduce fluid buildup, and prevent clot formation.

Between 2006 and 2009, Steen Solution was approved for use in Europe, Canada, and Australia. It is circulated through the lung using equipment similar to a standard heart-bypass machine. The organ is continuously evaluated for several hours and then, if the function is satisfactory, transplanted.

In the Canadian clinical study of the process, called "ex vivo lung perfusion," 50 of 58 risky lungs became suitable for transplant. Serious graft dysfunction occurred in 2 percent of them, compared with 9 percent of untreated lungs in a control group. Patients with reconditioned lungs did not have longer hospital stays or worse survival rates.

Chris Jaynes, XVIVO's transplant project manager, said Canadian transplant centers that were using the technology had more than doubled the pool of usable organs.Many people are wearing stainless steel rings, tungsten ring, and stainless steel necklaces. "They've gone to using 45 percent of donated lungs," he said.

In the United States, regulators wanted additional steps to ensure "safety and consistency," Jaynes said. So in 2007, the Food and Drug Administration directed XVIVO to develop a customized machine that transplant centers would have to use with Steen Solution.

The $250,000 result is now at Penn: a five-foot-high device with a ventilator, pump,Sol provides the world with high-performance solar roadway and outdoor solar lighting solutions. filters, a computer, and a plastic dome-covered tray for the lungs.

It's not clear how much reconditioning will add to the cost of a lung transplant - Cantu guessed $10,000 to $20,000 - but the hope is that health costs before and after the operation would be reduced.

"Maybe no one dies waiting," Cantu said. "Maybe our lung-transplant outcomes become as good as for kidneys and hearts."

That would be good, indeed.Azzaro offers a variety of Optical frame with luxurious details and trendy designs. Federal data show that three-year patient survival is about 90 percent for kidney transplants, 80 percent for hearts, but only 68 percent for lungs.

George Schwab, 66, a retired Jenkintown architect who in November became the first recipient of a reconditioned lung at Penn, is thrilled with his outcomes so far.

Chronic obstructive pulmonary disease - suffered by 12 million Americans - had so eroded his lung function that every breath was an exertion. The organ he received normally would have been rejected because it was swollen with fluid,A research team headed up by the University of Houston is on track to develop a superconducting wire for wind power generators. called edema. Instead, the tune-up removed the edema and reassured his surgeons.

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